Activation Strategies in Image-Guided Nanotherapeutic Delivery

Image-Guided Abdominal Surgery and Therapy Delivery.

Image-Guided Surgery has become the standard of care in intracranial neurosurgery providing more exact resections while minimizing damage to healthy tissue. Moving that process to abdominal organs presents additional challenges in the form of image segmentation, image to physical space registration, organ motion and deformation. In this paper, we present methodologies and results for addressing...

Mechanisms of drug release in nanotherapeutic delivery systems.

Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platform.

This paper provides a synopsis of the advancements made in advancing a dendrimer-based nanomedicine towards human clinical trials by the Michigan Nanotechnology Institute for Medicine and Biological Sciences. A brief description of the synthesis and characterization of a targeted multifunctional therapeutic will demonstrate the simple yet delicate task of producing novel chemotherapeutic agents...

Image guided focused ultrasound delivery of macromolecular drugs in tumours

Background/introduction Drug delivery using focused ultrasound (focal drug delivery) has attracted significant interest during the last few years. Focused Ultrasound (FUS) can induce local tissue hyperthermia, increasing blood flow and vascular permeability, which then enhances the uptake of therapeutics by target tissues. Although a number of studies have focused on nanoparticles (e.g. thermos...

Image Guided Biodistribution of Drugs and Drug Delivery

Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems. The application of these new materials and techniques with combined properties of diagnosis and therapy can benefit the development of targeted drug delivery system and modern personalized medicine This special issue provides an up-...